… Clearance and midazolam dose in neonates was also predicted … of midazolam clearance in
preterm neonates and term … 0.1 mg/kg midazolam given by intravenous (IV) infusion over 30 …

… the PK of oral and IV midazolam. Inclusion of IIV for clearance, volume of distribution, and …
bioavailability 3 than found in our patients, and vice versa for preterm neonates. Statistically …

… to predict the disposition of IV Midazolam in preterm neonates of different gestational ages,
… Clinical pharmacology and therapeutic drug monitoring in neonates and children. Pediatr. …

… individual differences exist in pharmacokinetic parameters for intravenous midazolam. …
in preterm neonates compared with that in older infants and children. Midazolam undergoes …

… preterm infants were undertaken for tracheal intubation following the use of atropine associated
to either midazolam … pain was assessed using premature infant pain profile (PIPP) score. …

… midazolam’s pharmacokinetics and pharmacodynamics, … A single dose of midazolam
co-administered with oral … the midazolam AUC 0–∞ by 219% after intravenous midazolam …

… our intravenous PBPK model that extended the predicted age to preterm. The simulation
results of the PD model showed that when the free concentrations of midazolam ranged from …

… Intravenous midazolam was used in 11 patients at the time of … Although IV morphine's
pharmacodynamics and … However, as drug elimination can be lengthened in preterm neonates, …

… time after intravenous induction is slower in neonates that in … very preterm infants, partially
useful in older preterm infants, … and effect in a neonate given protocol midazolam bolus (0.1 …

… is only relevant in preterm neonates as phenobarbital was … and midazolam can be extrapolated
to (near-)term neonates in general. As … neonates could be even greater. Extrapolation to …